{"id":114162,"date":"2022-10-11T09:02:54","date_gmt":"2022-10-11T07:02:54","guid":{"rendered":"https:\/\/ziacom.com\/?p=114162"},"modified":"2022-11-30T09:39:26","modified_gmt":"2022-11-30T08:39:26","slug":"gum-protein-prevent-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/ziacom.com\/en\/sector-news\/gum-protein-prevent-alzheimers-disease\/","title":{"rendered":"Gum protein may help prevent Alzheimer's disease"},"content":{"rendered":"

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<\/div>[vc_column_text]Based on the results of a study led by Antonio Nanci, researcher and professor in the Department of Stomatology at the <\/span>University of Montreal<\/span>, and the collaboration of researcher Charline Mari, as well as several colleagues from <\/span>Laval University<\/span> and <\/span>McGill University<\/span>, it has been observed that <\/span>a gum protein that fights the bacterium P. gingivalis may help prevent Alzheimer's disease.<\/span><\/b>\u00a0<\/span><\/p>\n

The importance of balancing the oral microbiome<\/span><\/b><\/h2>\n

The oral environment is the second most important microbiome in the body; in fact, <\/span>several studies<\/span><\/b>, such as the one led by Nanci, <\/span>have determined that its condition has a direct impact not only on the health of the oral cavity<\/span><\/b>, but also on general health.<\/span>\u00a0<\/span><\/p>\n

Nanci's study, which has been published in <\/span>Scientific Reports of the journal Nature<\/span><\/i>, has revealed that a protein present in the gingival epithelium may have antimicrobial properties against Porphyromonas gingivalis, a key pathogen in periodontal disease and whose presence can lead to systemic or neurodegenerative diseases such as Alzheimer's disease.<\/span>\u00a0<\/span><\/p>\n

It is believed that <\/span>overgrowth of <\/span><\/b>P. gingivalis<\/span><\/i><\/b> bacteria, which is part of the composition of oral biofilm, <\/span>can alter the body's immune response and increase the proliferation of oral biofilm to the point of causing biological disorders<\/span><\/b> leading to pathologies such as periodontal disease, which in turn can lead to diseases related to general health rather than exclusively oral health, such as Alzheimer's disease.<\/span>\u00a0<\/span><\/p>\n

The research suggests that <\/span>the secretory phosphoprotein produced by the gingival epithelium<\/span><\/b> to promote its adhesion to teeth, rich in proline and glutamine 1, <\/span>is bactericidal<\/span><\/b>, and they focused their research on this antibacterial potential and the identification of its active parts.<\/span>\u00a0<\/span><\/p>\n

They came to the following conclusions:<\/span>\u00a0<\/span><\/p>\n

    \n
  • In silico analysis demonstrated molecular parallelism with antimicrobial peptides.<\/span>\u00a0<\/span><\/li>\n
  • Incubation of Porphyromonas gingivalis with the full-length protein decreased bacterial numbers, aggregate formation and membrane alterations.<\/span>\u00a0<\/span><\/li>\n
  • Analysis of peptides derived from SCPPQ1 indicated that these effects are maintained in specific regions of the molecule.<\/span>\u00a0<\/span><\/li>\n<\/ul>\n

    These results suggest that this phosphoprotein has indeed antibacterial capacity, which opens new doors of research into its mechanism of action. Antonio Nanci: \"The antibacterial potential of this protein could be used not only to limit periodontal disease, but also as a treatment approach to control the effects of bacteria in the brain or other sites to which they spread\u201d.<\/span>\u00a0<\/span><\/p>\n

    The main risk factors for developing this disease include age, high blood pressure, hypercholesterolemia, obesity, sedentary lifestyle, smoking and diabetes.<\/span>\u00a0<\/span>[\/vc_column_text]

    <\/div>[vc_column_text]<\/p>\n

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    <\/div>[vc_basic_grid post_type=\"post\" max_items=\"10\" item=\"51432\" grid_id=\"vc_gid:1669293972227-1bb4045e-6158-5\" taxonomies=\"1882, 1978\"][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

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