Titanium allergy appears in dentistry more frequently than we think, affecting between 10% and 15% of the population.

Titanium is the material used par excellence in oral implantology.  Titanium allergy does not easily manifest because in the oral cavity is difficult to detect, Dental implants are fully buried into the bone and usually isolated from it by a layer of hydroxyapatite. The section that comes into contact with the peri-implant groove or the oral mucosa is passivated by a barrier of salivary glycoproteins and the oral mucosa is much more resistant to antigenic stimulation than the skin.

Titanium allergy in the human body is reflected by symptoms such as dermatitis, hives, vasculitis, specific immune suppression (Hallab 2001), chronic fatigue syndrome (Stejskall 1998).

Thanks to the MELISA test, allergy to metals can be detected and is the only scientifically validated test for this. The test is performed with a blood sample that measures hypersensitivity to metals and other allergens, pointing to the metal or metals causing the allergy and measuring the severity of the reaction according to a Stimulation Index (ESR).

Chronic exposure to metals: jewellery, implants or dental restorations, cosmetics, orthopaedic prostheses and even coins can sensitize genetically predisposed people and induce the so-called type IV hypersensitivity reaction. Vaccines, tattoos or piercings also contain metals that can affect your health if you have allergies.

Therefore, people who have dental fillings with amalgams, dental implants, bridges, people with metal prostheses, plates or screws from orthopedic operations, tattoos or piercings and present diffuse health disorders unrelated to a classic syndrome, may suspect metal allergy and may be justified to request a Melisa test. After the removal of metal fillers or metal allergy-inducing agents, the symptoms of metal allergy are significantly reduced in most patients.

Titanium in the human body can develop a type I and IV antigen and the existence of allergy to metals can aggravate various diseases such as fibromyalgia and multiple sclerosis, among others.